The Science Of VitamoreD
VitamoreD™ | Fast Acting, Vegan Vitamin D3
High potency with smaller doses. Calcifediol has been shown to be 3.2 x more potent than cholecalciferol. Meaning you can achieve higher, healthier blood levels of vitamin D with a much smaller dose.
VitamoreD gives your body and health a steady, potent supply of Vitamin D that can be tested, thus reducing any risk of toxicity.
Calcifediol | Vitamin D that is one step closer to being biologically active in the body.
87.5% of people taking 25D₃ (Calcifediol) had reached a healthy Vitamin D level (>30 ng/mL), compared to only 23.1% of those on D₃ (Cholecalciferol).
Calcifediol Research
Calcifediol is superior to cholecalciferol in improving vitamin D status in postmenopausal women
Participants: 303 vitamin D-deficient postmenopausal women.
Duration: 4 months (interim analysis at 4 months; ongoing for 12 months).
Key Results:
- After 4 months, 35% of women treated with calcifediol achieved vitamin D levels >30 ng/mL, versus only 8.2% treated with cholecalciferol (p < 0.0001).
- Blood vitamin D levels rose faster and more consistently with calcifediol.
- No serious adverse effects related to treatment.
Effects of cholecalciferol vs calcifediol on total and free vitamin D and PTH
Participants: 35 adults aged 18+ with baseline vitamin D levels <20 ng/mL.
Duration: 16-week randomized controlled trial.
Key Results:
- Calcifediol increased blood vitamin D levels nearly twice as much as cholecalciferol by week 4.
- 87.5% of calcifediol participants reached optimal levels ≥30 ng/mL at week 4 vs 23.1% for cholecalciferol.
- Improvements in parathyroid hormone (PTH) levels were strongly correlated with the increases in both total and free vitamin D levels.
Effect of calcifediol on physical performance and muscle strength parameters: a systematic review and meta-analysis
Participants: Data pooled from 7 randomized controlled trials; >5,400 participants combined.
Duration: Analysis included studies ranging from several weeks to several months.
Key Results:
Calcifediol significantly improved:
- Gait spee
- Handgrip strength
- Leg extension strength
- Positive effects were observed more reliably than previous vitamin D3-only studies.
Calcifediol: a review of its pharmacological characteristics and clinical use.
Participants: Literature review including clinical trials, population studies, and pharmacological analyses.
Duration: Review covered over 40 years of clinical experience.
Key Results:
- Calcifediol bypasses liver activation, offering faster correction of deficiency.
- More hydrophilic, allowing better absorption in malabsorptive conditions.
- Demonstrates a linear, predictable dose-response curve making it safer and simpler to dose.
Calcifediol: why, when, how much?
Vitamin D deficiency is a growing worldwide issue. In this narrative review and expert analysis researchers summarise over 40 years of clinical research, focusing on vitamin D metabolism and the benefits of calcifediol supplementation.
Advantages of Calcifediol
- Correction: raises blood 25(OH)D levels more quickly than cholecalciferol
- Potency: 2–5x more potent at low doses; up to 12x more potent at higher doses
- Absorption: absorbed via the portal system, not the lymphatic system, achieving 93% bioavailability even in people with gut diseases
- Activation: calcifediol activates Vitamin D receptors quickly at the cell membrane level offering faster biological responses.
- Safety: easy to monitor to avoid excessively serum concentrations