Perimenopause is a transitional time when oestrogen and progesterone begin to fluctuate, and these shifts don’t just affect your mood and cycle. They impact your immune system, skin barrier, and inflammatory response, too. The result? Skin that becomes more sensitive, reactive, and inflamed, even if you’ve never struggled with skin issues before.

You hit your 40s, and suddenly your skin starts reacting in ways it never did before. Redness. Breakouts. Flare-ups that look more like rashes than acne. Sound familiar? This isn’t just ‘ageing skin’, it’s often hormonal inflammation, and histamine is a major culprit.

Here’s what’s going on beneath the surface, and how to calm it down naturally.

1. Histamine: The Hidden Link Between Hormones and Skin Flares

Histamine is a natural immune chemical involved in inflammation, digestion, and allergic response. In balanced amounts, it’s helpful. But when it builds up, histamine can lead to flushing, hives, itching, breakouts, and puffiness, especially on the face and neck [1].

During perimenopause, oestrogen and progesterone levels fluctuate dramatically. Oestrogen naturally stimulates the release of histamine and also blocks the enzyme (DAO) that breaks it down [2]. When oestrogen spikes (or detox pathways are sluggish), histamine rises, and the skin often shows it first.

This can make women more sensitive to heat, stress, high-histamine foods (like wine, aged cheese, or chocolate), and even their own skin or personal care products.

2. Inflammation + Declining Collagen = Sensitive, Reactive Skin

As oestrogen dips, your skin’s ability to produce collagen and retain moisture also decreases [3]. Combined with increased histamine and immune reactivity, this creates a perfect storm: thinner skin, slower repair, and more visible signs of inflammation.

So those random breakouts, patches of redness, or ‘weird rashes’ that don’t respond to your usual products? They’re not just surface issues - they’re rooted in your body’s internal chemistry.

3. Toxaprevent Zeolite: Clearing Histamine Where It Starts

To calm perimenopausal skin, it’s not just about what you put on your face, it’s about what you help your body clear from it. This is where Toxaprevent, a clinically-backed natural zeolite supplement and topical, shines.

Zeolite (specifically Clinoptilolite) acts like a molecular magnet, binding to excess histamine, heavy metals, and toxins in the gut and on the skin’s surface [4]. This helps reduce the overall histamine load and gives the skin a chance to reset.

• Topically, it can help calm irritated, inflamed skin by directly binding histamine at the source.

• Internally, the oral form supports gut-based histamine clearance - key for women dealing with bloating, rosacea, or eczema during hormone fluctuations.
  

4. Other Ways to Support Hormone-Linked Inflammation

• Eat a low-histamine diet when symptoms flare, favouring fresh over fermented, and avoiding alcohol, smoked meats, and leftovers

• Support your liver and gut, where histamine breakdown happens

• Get enough magnesium and B6, both needed for DAO enzyme function and hormone balance [5]
  

• Practice stress reduction, since cortisol surges can worsen histamine reactivity
  

The Bottom Line

Perimenopausal skin changes aren’t just about ageing - they’re about inflammation and hormonal imbalance, with histamine at the centre. If your skin suddenly feels like it’s turned against you in your 40s, there’s a deeper reason, and a holistic path forward.

With smart nutrition, lifestyle shifts, and powerful natural tools, you can calm the storm, restore skin harmony, and feel like yourself again - inside and out.

Call us on 02476363873 or email us at hello@madebydaily.com to discuss your questions with a member of our clinical team.

Enjoyed this guide? Now read...

Why Women Over 35 Need to Consider Detoxing: The Link Between Toxins and Hormonal Imbalance
Why Your Glass of Wine Hits Differently Now: The Alcohol and Histamine Connection
Hormone imbalance and histamine intolerance

References
1. Maintz, L., & Novak, N. (2007). Histamine and histamine intolerance. Am J Clin Nutr.
2. Rivera, E., & Peters, B. (2021). Histamine and estrogen: The unexplored connection in perimenopause. Horm Mol Biol Clin Investig.
3. Brincat, M. (2000). Hormone replacement therapy and the skin. Maturitas.
4. Kaufhold, S. et al. (2010). Clinoptilolite zeolite: Toxin-binding properties and applications. Microporous and Mesoporous Materials.
5. Eedy, D. J., & Rogers, S. (1987). Vitamin B6 in dermatology: A review. Clin Exp Dermatol.